Dr. Stern's CBD Notes:

Mission Statement

Here is some useful information and have attached links to research base articles for some of the conditions for your viewing. Providing information and educational materials is the first step to understanding what CBD products can do for you.

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Several studies point to the potential benefits of CBD for anxiety. For generalized anxiety, the National Institute on Drug Abuse says that CBD has been shown to reduce stress in animal studies. Study subjects were observed as having lower behavioral signs of anxiety. Their physiological symptoms of anxiety, like increased heart rate, also improved. Several studies point to the potential benefits of CBD for anxiety. For generalized anxiety, the National Institute on Drug Abuse says that CBD has been shown to reduce stress in animal studies. Study subjects were observed as having lower behavioral signs of anxiety. Their physiological symptoms of anxiety, like increased heart rate, also improved. Studies have also shown some benefits for other forms of anxiety, such as social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD). CBD may also help treat anxiety-induced insomnia. In 2011, a human study on CBD and its effects on SAD was published in the Journal of Psychopharmacology. Participants were given either an oral dose of 400 milligrams of CBD or a placebo. The results showed that those who took the CBD dose experienced overall reduced anxiety levels.

https://www.healthline.com/health/cbd-for-anxiety#is-it-legal

Inflammation in the central nervous system (CNS) is a complex process that involves a multitude of molecules and effectors, and it requires the transmigration of blood leukocytes across the blood-brain barrier (BBB) and the activation of resident immune cells. Cannabidiol (CBD), a non-psychotropic cannabinoid constituent of Cannabis sativa, has potent anti-inflammatory and immunosuppressive properties. Yet, how this compound modifies the deleterious effects of inflammation in TMEV-induced demyelinating disease (TMEV-IDD) remains unknown. Using this viral model of multiple sclerosis (MS), we demonstrate that CBD decreases the transmigration of blood leukocytes by downregulating the expression of vascular cell adhesion molecule-1 (VCAM-1), chemokines (CCL2 and CCL5) and the proinflammatory cytokine IL-1β, as well as by attenuating the activation of microglia. Moreover, CBD administration at the time of viral infection exerts long-lasting effects, ameliorating motor deficits in the chronic phase of the disease in conjunction with reduced microglial activation and pro-inflammatory cytokine production. Adenosine A2A receptors participate in some of the anti-inflammatory effects of CBD, as the A2A antagonist ZM241385 partially blocks the protective effects of CBD in the initial stages ofinflammation. Together, our findings highlight the anti-inflammatory effects of CBD in this viral model of MS and demonstrate the significant therapeutic potential of this compound for the treatment of pathologies with an inflammatory component.

http://www.cbdunlimited.com/wp-content/uploads/2015/07/CBD-Inflammation.pdf

Studies indicate that the cannabinoids found within cannabis can help manage psoriasis through their interaction with the endocannabinoid system. When the endocannabinoid system is disrupted, it can lead to the development of autoimmune diseases like psoriasis. However, studies show that cannabinoids’ interaction with cannabinoid receptors within the endocannabinoid system (ECS) help regulate proper function of the immune system2,5,10. Earlier clinical trial data found that cannabis helps prevent psoriasis flare-ups by activating the cannabinoid 2 (CB2) receptors of the ECS4. Most recently, a literature review concluded that cannabinoids’ anti-inflammatory effects and their regulating affects on the immune system make them a potential treatment agent for psoriasis3.
Research also suggests that cannabis can help treat psoriasis symptoms by managing the over activity of T cells. One study found that cannabinoid’s interaction with cannabis receptors of the body’s ECS is implicated in several biological processes related to the skin, including proliferation of skin cells1. A later study determined that CB receptors likely play a circumstantial role in T cell activity, but that cannabis’ ability to inhibit the activity of the cells is unrelated to its activation of CB receptors11. Four of the major cannabinoids found within cannabis, including tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN) and cannabigerol (CBG), have been shown to effectively inhibit overactive T cells and thereby play a therapeutic role in psoriasis treatment efforts11.
Additionally, studies have found that through the activation of CB2 receptors, cannabinoids can help alleviate, and in some cases reverse, skin inflammation damage6.

Acne treatment is another promising use for CBD. The condition is caused, in part, by inflammation and overworked sebaceous glands in the body.
A 2014 study published by the Journal of Clinical Investigation found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect on the body. Sebum is an oily substance, and overproduction can cause acne.
CBD could become a future treatment for acne vulgaris, the most common form of acne